Structure of PDB 1b0m Chain A

Receptor sequence
>1b0mA (length=753) Species: 9823 (Sus scrofa) [Search protein sequence]
RAKVAMSHFEPHEYIRYDLLEKNIDIVRKRLNRPLTLSEKIVYGHLDDPA
NQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDH
LIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIIL
ENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPK
VIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCT
GMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLADEFKDHLVP
DPGCHYDQVIEINLSELKPHINGPFTPDLAHPVAEVGSVAEKEGWPLDIR
VGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIE
RDGYAQVLRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTG
RNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPD
ADELPRAEFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKD
LEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENRK
ANSVRNAVTQEFGPVPDTARYYKQHGIRWVVIGDENYGEGSSQEHSALEP
RHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQG
LKDFAPGKPLKCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKEL
QQK
3D structure
PDB1b0m The mechanism of aconitase: 1.8 A resolution crystal structure of the S642a:citrate complex.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D100 H101 D165 R447 S642 Q644
Catalytic site (residue number reindexed from 1) D99 H100 D164 R446 S641 Q643
Enzyme Commision number 4.2.1.3: aconitate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC A Q72 H101 D165 S166 R452 R580 S642 S643 Q644 Q71 H100 D164 S165 R451 R579 S641 S642 Q643
BS02 SF4 A H101 I145 H147 H167 S357 C358 C421 C424 I425 N446 H100 I144 H146 H166 S356 C357 C420 C423 I424 N445
Gene Ontology
Molecular Function
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1b0m, PDBe:1b0m, PDBj:1b0m
PDBsum1b0m
PubMed10631981
UniProtP16276|ACON_PIG Aconitate hydratase, mitochondrial (Gene Name=ACO2)

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