Structure of PDB 1b02 Chain A

Receptor sequence
>1b02A (length=279) Species: 1423 (Bacillus subtilis) [Search protein sequence]
MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRF
DNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQE
DGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNP
DELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQ
RMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPE
VKDFYDFTIDDFKLINYKHGDKLLFEVAV
3D structure
PDB1b02 Crystal structure of thymidylate synthase A from Bacillus subtilis.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E71 W94 Y108 C161 R181 D184 F191
Catalytic site (residue number reindexed from 1) E71 W94 Y108 C161 R181 D184 F191
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UFP A R28 C161 R181 S182 N183 D184 N192 H222 Y224 R28 C161 R181 S182 N183 D184 N192 H222 Y224
BS02 C2F A I93 W94 W97 D184 G188 A278 I93 W94 W97 D184 G188 A278
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:1b02, PDBe:1b02, PDBj:1b02
PDBsum1b02
PubMed10091656
UniProtP0CI79|TYSY1_BACSU Thymidylate synthase 1 (Gene Name=thyA1)

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