Structure of PDB 1ayw Chain A

Receptor sequence
>1aywA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSP
QNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY
YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
3D structure
PDB1ayw Design of potent and selective human cathepsin K inhibitors that span the active site.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IN3 A N18 Q19 G20 G23 C25 G66 Y67 D158 L160 N161 H162 A163 W184 L209 N18 Q19 G20 G23 C25 G66 Y67 D158 L160 N161 H162 A163 W184 L209 BindingDB: Ki=27nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ayw, PDBe:1ayw, PDBj:1ayw
PDBsum1ayw
PubMed9405598
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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