Structure of PDB 1axc Chain A
Receptor sequence
>1axcA (length=249) Species:
9606
(Homo sapiens) [
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MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQL
TLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLA
LVFEAPEKVSDYEMKLMDLDVEQLGIPEQEYSCVVKMPSGEFARICRDLS
HIGDAVVISCAKDGVKFSASGELGNGNIKLSQTSEEEAVTIEMNEPVQLT
FALRYLNFFTKATPLSSTVTLSMSADVPLVVEYKIADMGHLKYYLAPKI
3D structure
PDB
1axc
Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.
Chain
A
Resolution
2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
peptide
A
C27 D29 M40 H44 V45 G69 D97 M119 D120 L121 D122 V123 E124 Q125 L126 G127 Q131 D232 P234 A252 P253 K254 I255
C27 D29 M40 H44 V45 G69 D97 M117 D118 L119 D120 V121 E122 Q123 L124 G125 Q129 D226 P228 A246 P247 K248 I249
Gene Ontology
Molecular Function
GO:0000701
purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003677
DNA binding
GO:0003682
chromatin binding
GO:0003684
damaged DNA binding
GO:0005515
protein binding
GO:0019899
enzyme binding
GO:0030331
nuclear estrogen receptor binding
GO:0030337
DNA polymerase processivity factor activity
GO:0030971
receptor tyrosine kinase binding
GO:0032139
dinucleotide insertion or deletion binding
GO:0032405
MutLalpha complex binding
GO:0035035
histone acetyltransferase binding
GO:0042802
identical protein binding
GO:0044877
protein-containing complex binding
GO:0070182
DNA polymerase binding
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0006260
DNA replication
GO:0006272
leading strand elongation
GO:0006275
regulation of DNA replication
GO:0006281
DNA repair
GO:0006287
base-excision repair, gap-filling
GO:0006298
mismatch repair
GO:0006979
response to oxidative stress
GO:0007507
heart development
GO:0019985
translesion synthesis
GO:0030855
epithelial cell differentiation
GO:0031297
replication fork processing
GO:0032077
positive regulation of deoxyribonuclease activity
GO:0032355
response to estradiol
GO:0033993
response to lipid
GO:0034644
cellular response to UV
GO:0044849
estrous cycle
GO:0045739
positive regulation of DNA repair
GO:0045740
positive regulation of DNA replication
GO:0046686
response to cadmium ion
GO:0070301
cellular response to hydrogen peroxide
GO:0071466
cellular response to xenobiotic stimulus
GO:0071548
response to dexamethasone
GO:0097421
liver regeneration
GO:1900264
positive regulation of DNA-directed DNA polymerase activity
GO:1902065
response to L-glutamate
GO:1902990
mitotic telomere maintenance via semi-conservative replication
Cellular Component
GO:0000307
cyclin-dependent protein kinase holoenzyme complex
GO:0000781
chromosome, telomeric region
GO:0000785
chromatin
GO:0001673
male germ cell nucleus
GO:0005634
nucleus
GO:0005652
nuclear lamina
GO:0005654
nucleoplasm
GO:0005657
replication fork
GO:0005813
centrosome
GO:0016604
nuclear body
GO:0030894
replisome
GO:0043596
nuclear replication fork
GO:0043626
PCNA complex
GO:0070062
extracellular exosome
GO:0070557
PCNA-p21 complex
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1axc
,
PDBe:1axc
,
PDBj:1axc
PDBsum
1axc
PubMed
8861913
UniProt
P12004
|PCNA_HUMAN Proliferating cell nuclear antigen (Gene Name=PCNA)
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