Structure of PDB 1avf Chain A

Receptor sequence
>1avfA (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
VTYEPMAYMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACT
SHSRFNPSESSTYSTNGQTFSLQSGSLTGFFGYDTLTVQSIQVPNQEFGL
SENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSV
YLSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIEEFLIGGQASGWCS
EGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPS
LTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFL
RSYYSVYDLGNNRVGFATAA
3D structure
PDB1avf Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.3: gastricsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M7 M10 D11 A12 A13 Y14 F15 G16 L28 Q92 I94 N111 Y114 A115 Q116 L146 T147 G163 G164 A165 V166 V167 F168 M6 M9 D10 A11 A12 Y13 F14 G15 L27 Q89 I91 N108 Y111 A112 Q113 L143 T144 G154 G155 A156 V157 V158 F159
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1avf, PDBe:1avf, PDBj:1avf
PDBsum1avf
PubMed9406551
UniProtP20142|PEPC_HUMAN Gastricsin (Gene Name=PGC)

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