Structure of PDB 1av6 Chain A

Receptor sequence
>1av6A (length=289) Species: 10254 (Vaccinia virus WR) [Search protein sequence]
VVSLDKPFMYFEEIDNELDYEPESANEVAKKLPYQGQLKLLLGELFFLSK
LQRHGILDGATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPI
LNGLRDVTLVTRFVDEEYLRSIKKQLHPSKIILISDVRSPSTADLLSNYA
LQNVMISILNPVASSLKWRCPFPDQWIKDFYIPHGNKMLQPFAPSYSAEM
RLLSIYTGENMRLTRVTKSDAVNYEKKMYYLNKIVRNKVVVNFDYPNQEY
DYFHMYFMLRTVYCNKTFPTTKAKVLFLQQSIFRFLNIP
3D structure
PDB1av6 Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K32 Y36 G38 Q39 K41 P71 K175 E207 K30 Y34 G36 Q37 K39 P69 K167 E199
BS02 MGT A Y22 P148 R177 F180 D182 S205 E233 Y20 P140 R169 F172 D174 S197 E225
BS03 SAH A Q39 L42 Y66 G68 A70 P71 G72 H74 D95 F115 V116 D138 Q37 L40 Y64 G66 A68 P69 G70 H72 D93 F113 V114 D136
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0031440 regulation of mRNA 3'-end processing

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Molecular Function
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Biological Process
External links
PDB RCSB:1av6, PDBe:1av6, PDBj:1av6
PDBsum1av6
PubMed9660928
UniProtP07617|MCE_VACCW Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (Gene Name=OPG102)

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