Structure of PDB 1aog Chain A

Receptor sequence
>1aogA (length=485) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
SKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGT
CVNVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKNLIAVKDE
AVLNINKSYDEMFRDTEGLEFFLGWGSLESKNVVNVRESADPASAVKERL
ETEHILLASGSWPHMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISV
EFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQLTANGIQILT
KENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGV
MIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGT
TPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHK
VSGSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKIS
DFYNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKP
3D structure
PDB1aog The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S15 L49 C53 C58 K61 R86 T87 F199 E203 I339 G459 H461 E466 E485 K486
Catalytic site (residue number reindexed from 1) S13 L47 C51 C56 K59 R84 T85 F197 E201 I337 G457 H459 E464 E483 K484
Enzyme Commision number 1.8.1.12: trypanothione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I11 G12 G14 S15 D36 V37 S47 A48 G51 T52 C53 G57 C58 K61 W127 G128 S161 G162 F199 R288 R291 G326 D327 M333 L334 T335 I9 G10 G12 S13 D34 V35 S45 A46 G49 T50 C51 G55 C56 K59 W125 G126 S159 G160 F197 R286 R289 G324 D325 M331 L332 T333
Gene Ontology
Molecular Function
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0015036 disulfide oxidoreductase activity
GO:0015042 trypanothione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1aog, PDBe:1aog, PDBj:1aog
PDBsum1aog
PubMed8771196
UniProtP28593|TYTR_TRYCR Trypanothione reductase (Gene Name=TPR)

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