Structure of PDB 1aod Chain A

Receptor sequence
>1aodA (length=274) Species: 1639 (Listeria monocytogenes) [Search protein sequence]
VTTKQWMSALPDTTNLAALSIPGTHDTMSYNGDITWTLTKPLAQTQTMSL
YQQLEAGIRYIDIRAKDNLNIYHGPIFLNASLSGVLETITQFLKKNPKET
IIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRG
KILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEIVQ
TAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVR
GLGILIMDFPEKQTIKNIIKNNKF
3D structure
PDB1aod Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenes.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H45 D46 R84 H93 D278
Catalytic site (residue number reindexed from 1) H25 D26 R64 H73 D258
Enzyme Commision number 4.6.1.13: phosphatidylinositol diacylglycerol-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 INS A H45 R84 R124 K126 D204 Y206 H25 R64 R104 K106 D184 Y186
Gene Ontology
Molecular Function
GO:0004436 phosphatidylinositol diacylglycerol-lyase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016829 lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1aod, PDBe:1aod, PDBj:1aod
PDBsum1aod
PubMed9367761
UniProtP34024|PLC_LISMO 1-phosphatidylinositol phosphodiesterase (Gene Name=plcA)

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