Structure of PDB 1amj Chain A

Receptor sequence
>1amjA (length=753) Species: 9913 (Bos taurus) [Search protein sequence]
RAKVAMSHFEPHEYIRYDLLEKNIDIVRKRLNRPLTLSEKIVYGHLDDPA
NQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDH
LIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIIL
ENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPK
VIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCT
GMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLADEFKDHLVP
DSGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGSVAEKEGWPLDIR
VGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIE
RDGYAQVLRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTG
RNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPD
ADELPRAEFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKD
LEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINSENRK
ANSVRNAVTQEFGPVPDTARYYKQHGIRWVVIGDENYGEGSSREHSALEP
RFLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQG
LKDFAPGKPLTCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKEL
QQK
3D structure
PDB1amj Steric and conformational features of the aconitase mechanism.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D100 H101 D165 R447 S642 R644
Catalytic site (residue number reindexed from 1) D99 H100 D164 R446 S641 R643
Enzyme Commision number 4.2.1.3: aconitate hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A Q72 R580 R644 Q71 R579 R643
BS02 SF4 A I145 H167 C358 C421 C424 I144 H166 C357 C420 C423
Gene Ontology
Molecular Function
GO:0003994 aconitate hydratase activity
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1amj, PDBe:1amj, PDBj:1amj
PDBsum1amj
PubMed7675781
UniProtP20004|ACON_BOVIN Aconitate hydratase, mitochondrial (Gene Name=ACO2)

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