Structure of PDB 1alq Chain A

Receptor sequence
>1alqA (length=259) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
SEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEFAAAAKELNDLEKKYN
AHIGVYALDTKSGKEVKFNSDKRFAYASTSKAINSAILLEQVPYNKLNKK
VHINKDDIVAYSPILEKYVGKDITLKALIEASMTYSDNTANNKIIKEIGG
IKKVKQRLKELGDKVTNPVRYEIELNYYSPKSKKDTSTPAAFGKTLNKLI
ANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQAITYASR
NDVAFVYPK
3D structure
PDB1alq Circularly permuted beta-lactamase from Staphylococcus aureus PC1.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S130 E166 K234 Q237
Catalytic site (residue number reindexed from 1) S78 K81 S136 E172 K240 Q243
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO3 A S176 K177 S182 K183
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1alq, PDBe:1alq, PDBj:1alq
PDBsum1alq
PubMed9220963
UniProtP00807|BLAC_STAAU Beta-lactamase (Gene Name=blaZ)

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