Structure of PDB 1aky Chain A

Receptor sequence
>1akyA (length=218) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLE
AKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDGFPRTIPQAEKLD
QMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKED
MKDDVTGEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDA
SQPPATVWADILNKLGKN
3D structure
PDB1aky High-resolution structures of adenylate kinase from yeast ligated with inhibitor Ap5A, showing the pathway of phosphoryl transfer.
ChainA
Resolution1.63 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K17 R93 R132 R165 R176
Catalytic site (residue number reindexed from 1) K15 R91 R130 R163 R174
Enzyme Commision number 2.7.4.3: adenylate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AP5 A G14 G16 K17 G18 T19 T35 R40 M57 G61 V63 M68 G90 R93 Q97 R128 R132 S141 Y142 H143 R165 R176 P206 G12 G14 K15 G16 T17 T33 R38 M55 G59 V61 M66 G88 R91 Q95 R126 R130 S139 Y140 H141 R163 R174 P204
BS02 IMD A G18 D89 G16 D87
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0004017 adenylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019205 nucleobase-containing compound kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006172 ADP biosynthetic process
GO:0006270 DNA replication initiation
GO:0009117 nucleotide metabolic process
GO:0016310 phosphorylation
GO:0036388 pre-replicative complex assembly
GO:0046033 AMP metabolic process
GO:0046034 ATP metabolic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1aky, PDBe:1aky, PDBj:1aky
PDBsum1aky
PubMed7670369
UniProtP07170|KAD2_YEAST Adenylate kinase (Gene Name=ADK1)

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