Structure of PDB 1ahz Chain A

Receptor sequence

>1ahzA (length=555) Species: 69488 (Penicillium simplicissimum) [Search protein sequence]

EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISSKDQIVDGSYMKPT
HTHDPHHVMDQDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRN
SGYGGAAPRVSGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYL
EANNLRDKLWLDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLA
NGELLRTGMGALPDPKRPETMGLKPEDQPWSKIAHLFPYGFGPYIDGLFS
QSNMGIVTKIGIWLMPNPRGYQSYLITLPKDGDLKQAVDIIRPLRLGMAL
QNVPTIRHILLDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYG
ALYGPEPIRRVLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGI
PTYDELKWIDWLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDFI
GTFTVGMREMHHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRT
HLAFMDQIMETYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSH
VTWKL

3D structure

PDB

1ahz Crystal structures and inhibitor binding in the octameric flavoenzyme vanillyl-alcohol oxidase: the shape of the active-site cavity controls substrate specificity.

Chain

Resolution

3.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y108 D170 E182 D192 D317 V397 E410 I414 H422 H466 Y503 R504 K545
Catalytic site (residue number reindexed from 1)	Y103 D165 E177 D187 D312 V392 E405 I409 H417 H461 Y498 R499 K540
Enzyme Commision number	1.1.3.38: vanillyl-alcohol oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	S101 I102 G103 R104 N105 P169 D170 L171 S175 N179 E182 Y187 I261 V262 W413 H422 F424 R504 K545	S96 I97 G98 R99 N100 P164 D165 L166 S170 N174 E177 Y182 I256 V257 W408 H417 F419 R499 K540
BS02	EPT	A	Y108 D170 R312 R398 F424 T457 I468 Y503	Y103 D165 R307 R393 F419 T452 I463 Y498

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004458	D-lactate dehydrogenase (cytochrome) activity
GO:0008720	D-lactate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0018465	vanillyl-alcohol oxidase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

	Biological Process
GO:0015945	methanol metabolic process
GO:1903457	lactate catabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1ahz, PDBe:1ahz, PDBj:1ahz
PDBsum	1ahz
PubMed	9261083
UniProt	P56216\|VAOX_PENSI Vanillyl-alcohol oxidase (Gene Name=VAOA)

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