Structure of PDB 1ahh Chain A

Receptor sequence
>1ahhA (length=253) Species: 562 (Escherichia coli) [Search protein sequence]
MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANH
VVDEIQQLGGQAFACRCDITSEQELSALADFAISKLGKVDILVNNAGGGG
PKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAE
NKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSV
ITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSGQILTVSGGG
VQE
3D structure
PDB1ahh Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G22 S146 M156 Y159 K163
Catalytic site (residue number reindexed from 1) G22 S146 M156 Y159 K163
Enzyme Commision number 1.1.1.159: 7alpha-hydroxysteroid dehydrogenase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 NAD A G18 A21 D42 I43 C67 D68 I69 N95 G97 T145 Y159 K163 P189 G190 I192 G18 A21 D42 I43 C67 D68 I69 N95 G97 T145 Y159 K163 P189 G190 I192
Gene Ontology
Molecular Function
GO:0008709 cholate 7-alpha-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0051287 NAD binding
GO:0106281 chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
Biological Process
GO:0016042 lipid catabolic process
GO:0030573 bile acid catabolic process
Cellular Component
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Cellular Component
External links
PDB RCSB:1ahh, PDBe:1ahh, PDBj:1ahh
PDBsum1ahh
PubMed8672472
UniProtP0AET8|HDHA_ECOLI 7alpha-hydroxysteroid dehydrogenase (Gene Name=hdhA)

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