Structure of PDB 1ah5 Chain A

Receptor sequence
>1ah5A (length=299) Species: 562 (Escherichia coli) [Search protein sequence]
DNVLRIATRQSPLALWQAHYVKDKLMASHPGLVVELVPMVTRGDKGLFVK
ELEVALLENRADIAVHSMKDVPVEFPQGLGLVTICEREDPRDAFVSNNYD
SLDALPAGSIVGTSSLRRQCQLAERRPDLIIRSLRGNVGTRLSKLDNGEY
DAIILAVAGLKRLGLESRIRAALPPEISLPAVGQGAVGIECRLDDSRTRE
LLAALNHHETALRVTAERAMNTRLEGGCQVPIGSYAELIDGEIWLRALVG
APDGSQIIRGERRGAPQDAEQMGISLAEELLNNGAREILAEVYNGDAPA
3D structure
PDB1ah5 Determination of the structure of seleno-methionine-labelled hydroxymethylbilane synthase in its active form by multi-wavelength anomalous dispersion.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K83 D84 R131 R132 R149 R155 C242
Catalytic site (residue number reindexed from 1) K69 D70 R117 R118 R135 R141 C228
Enzyme Commision number 2.5.1.61: hydroxymethylbilane synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DPM A S81 K83 D84 T127 S128 S129 R131 R132 R155 L169 A170 C242 S67 K69 D70 T113 S114 S115 R117 R118 R141 L155 A156 C228
Gene Ontology
Molecular Function
GO:0004418 hydroxymethylbilane synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0018160 peptidyl-pyrromethane cofactor linkage
GO:0033014 tetrapyrrole biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1ah5, PDBe:1ah5, PDBj:1ah5
PDBsum1ah5
PubMed10089459
UniProtP06983|HEM3_ECOLI Porphobilinogen deaminase (Gene Name=hemC)

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