Structure of PDB 1ae4 Chain A

Receptor sequence
>1ae4A (length=324) Species: 9823 (Sus scrofa) [Search protein sequence]
AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIYG
NELEIGEALTETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLAD
LQLEYLDLYLMHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEALV
AKGLVRALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQ
ARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEKYNRSPAQILLR
WQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIVP
MLTVDGKRVPRDAGHPLYPFNDPY
3D structure
PDB1ae4 Studies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complex.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D45 Y50 K80 H113
Catalytic site (residue number reindexed from 1) D44 Y49 K79 H112
Enzyme Commision number 1.1.1.19: glucuronate reductase.
1.1.1.2: alcohol dehydrogenase (NADP(+)).
1.1.1.20: glucuronolactone reductase.
1.1.1.372: D/L-glyceraldehyde reductase.
1.1.1.54: allyl-alcohol dehydrogenase.
1.6.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G20 S211 S215 S264 G19 S210 S214 S263
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0047655 allyl-alcohol dehydrogenase activity
GO:0047939 L-glucuronate reductase activity
GO:0047941 glucuronolactone reductase activity
GO:0047956 glycerol dehydrogenase (NADP+) activity
GO:0160163 S-nitrosoglutathione reductase (NADPH) activity
GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity
Biological Process
GO:0006629 lipid metabolic process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0042840 D-glucuronate catabolic process
GO:0046185 aldehyde catabolic process
GO:0110095 cellular detoxification of aldehyde
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane

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Cellular Component
External links
PDB RCSB:1ae4, PDBe:1ae4, PDBj:1ae4
PDBsum1ae4
PubMed9329083
UniProtP50578|AK1A1_PIG Aldo-keto reductase family 1 member A1 (Gene Name=AKR1A1)

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