Structure of PDB 1ad5 Chain A

Receptor sequence
>1ad5A (length=438) Species: 9606 (Homo sapiens) [Search protein sequence]
EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYI
PSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKG
SYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKK
GNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWM
ATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEP
IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYI
HRDLRAANILVSASLVCKIADFGLARVGAKFPIKWTAPEAINFGSFTIKS
DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYN
IMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
3D structure
PDB1ad5 Crystal structure of the Src family tyrosine kinase Hck.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 G406 P425
Catalytic site (residue number reindexed from 1) D303 R305 A307 N308 D321 G323 P332
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N391 D404 N308 D321
BS02 ANP A L273 G276 V281 A293 K295 F340 M341 L393 L190 G193 V198 A210 K212 F257 M258 L310
BS03 CA A E524 Y527 Q529 E431 Y434 Q436
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ad5, PDBe:1ad5, PDBj:1ad5
PDBsum1ad5
PubMed9024658
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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