Structure of PDB 1ab8 Chain A

Receptor sequence
>1ab8A (length=177) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLL
SKPKFSGVEKIKTIGSTYMAATGLSAIPSQQYMHIGTMVEFAYALVGKLD
AINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTG
VLDKIQVTEETSLILQTLGYTCTCFVN
3D structure
PDB1ab8 Structure of the adenylyl cyclase catalytic core.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S891 I892 S942 R1029
Catalytic site (residue number reindexed from 1) S15 I16 S66 R145
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FOK A F889 K938 D1018 I1019 W1020 G1021 V1024 N1025 F13 K62 D134 I135 W136 G137 V140 N141
BS02 FOK A K896 G941 S942 K20 G65 S66
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1ab8, PDBe:1ab8, PDBj:1ab8
PDBsum1ab8
PubMed9069282
UniProtP26769|ADCY2_RAT Adenylate cyclase type 2 (Gene Name=Adcy2)

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