Structure of PDB 1a80 Chain A

Receptor sequence
>1a80A (length=277) Species: 1720 (Corynebacterium sp.) [Search protein sequence]
TVPSIVLNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYG
NEEGVGAAIAASGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQ
VDLYLVHWPTPAADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVA
ATGVVPAVNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYDLFGAE
PVTAAAAAHGKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLT
DTEIAAIDAMDPGDGSGRVSAHPDEVD
3D structure
PDB1a80 Crystal structure of 2,5-diketo-D-gluconic acid reductase A complexed with NADPH at 2.1-A resolution.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D45 Y50 K75 H108
Catalytic site (residue number reindexed from 1) D44 Y49 K74 H107
Enzyme Commision number 1.1.1.346: 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G20 F22 D45 Y50 H108 S139 Q161 W187 G188 P189 L190 Q192 A215 F230 K232 S233 V234 R235 R238 E241 N242 G19 F21 D44 Y49 H107 S138 Q160 W186 G187 P188 L189 Q191 A214 F229 K231 S232 V233 R234 R237 E240 N241
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0019853 L-ascorbic acid biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1a80, PDBe:1a80, PDBj:1a80
PDBsum1a80
PubMed9618487
UniProtP06632|DKGA_CORSC 2,5-diketo-D-gluconic acid reductase A (Gene Name=dkgA)

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