Structure of PDB 1a5i Chain A

Receptor sequence
>1a5iA (length=265) Species: 9430 (Desmodus rotundus) [Search protein sequence]
TCGLRKYKEPQLHSTGGLFTDITSHPWQAAIFAQNRRSSGERFLCGGILI
SSCWVLTAAHCFQESYLPDQLKVVLGRTYRVKPGEEEQTFKVKKYIVHKE
FDDDTYNNDIALLQLKSDSPQCAQESDSVRAICLPEANLQLPDWTECELS
GYGKHKSSSPFYSEQLKEGHVRLYPSSRCAPKFLFNKTVTNNMLCAGDTR
SGEIYPNVHDACQGDSGGPLVCMNDNHMTLLGIISWGVGCGEKDVPGVYT
KVTNYLGWIRDNMHL
3D structure
PDB1a5i Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H60 D109 Q213 G214 D215 S216 G217
Enzyme Commision number 3.4.21.68: t-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0GJ A H57 Y99 D189 A190 C191 Q192 G193 S195 S214 W215 G216 G219 H60 Y106 D210 A211 C212 Q213 G214 S216 S235 W236 G237 G239
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1a5i, PDBe:1a5i, PDBj:1a5i
PDBsum1a5i
PubMed9354616
UniProtP98119|URT1_DESRO Salivary plasminogen activator alpha 1

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