Structure of PDB 1a5h Chain A

Receptor sequence
>1a5hA (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALL
QLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYS
ERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQ
GDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNM
RP
3D structure
PDB1a5h Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 G193 S195
Catalytic site (residue number reindexed from 1) H47 D96 G201 S203
Enzyme Commision number 3.4.21.68: t-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S26 H27 W29 R119 T120 C122 E137 R206 M207 S11 H12 W14 R117 T118 C120 E135 R214 M215
BS02 BBA A D97 T98 Y99 D189 A190 Q192 I213 W215 G216 G219 D91 T92 Y93 D197 A198 Q200 I221 W223 G224 G226 PDBbind-CN: -logKd/Ki=6.30,Ki=0.5uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1a5h, PDBe:1a5h, PDBj:1a5h
PDBsum1a5h
PubMed9268299
UniProtP00750|TPA_HUMAN Tissue-type plasminogen activator (Gene Name=PLAT)

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