Structure of PDB 1a52 Chain A

Receptor sequence
>1a52A (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHERLA
QLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEML
3D structure
PDB1a52 Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST A E353 L387 M388 L391 F404 H524 L525 E48 L82 M83 L86 F99 H219 L220 PDBbind-CN: -logKd/Ki=9.86,Ki=0.138nM
BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1a52, PDBe:1a52, PDBj:1a52
PDBsum1a52
PubMed9600906
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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