Structure of PDB 1a4z Chain A

Receptor sequence
>1a4zA (length=493) Species: 9913 (Bos taurus) [Search protein sequence]
VPTPNQQPEVLYNQIFINNEWHDAVSKKTFPTVNPSTGDVICHVAEGDKA
DVDRAVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALET
LDNGKPYIISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDYFSYTRHE
PVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANL
IKEAGFPPGVVNVIPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAA
GKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSR
TFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKVLGYI
KSGKEEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQI
LKFKSMEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYD
VFGAQSPFGGYKLSGSGRELGEYGLQAYTEVKTVTVRVPQKNS
3D structure
PDB1a4z Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 K192 E268 C302 E399 E476
Catalytic site (residue number reindexed from 1) N162 K185 E261 C295 E392 E469
Enzyme Commision number 1.2.1.3: aldehyde dehydrogenase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A I165 I166 P167 W168 N169 M174 K192 E195 G225 P226 G229 A230 T244 G245 S246 V249 E268 I269 G270 C302 E399 F401 I158 I159 P160 W161 N162 M167 K185 E188 G218 P219 G222 A223 T237 G238 S239 V242 E261 I262 G263 C295 E392 F394
Gene Ontology
Molecular Function
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0008957 phenylacetaldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
GO:0106435 carboxylesterase activity
Biological Process
GO:0006068 ethanol catabolic process
GO:0018937 nitroglycerin metabolic process
GO:0046185 aldehyde catabolic process
GO:1903179 regulation of dopamine biosynthetic process
GO:1905627 regulation of serotonin biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a4z, PDBe:1a4z, PDBj:1a4z
PDBsum1a4z
PubMed9195888
UniProtP20000|ALDH2_BOVIN Aldehyde dehydrogenase, mitochondrial (Gene Name=ALDH2)

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