Structure of PDB 1a4q Chain A

Receptor sequence
>1a4qA (length=390) Species: 11525 (Influenza B virus (STRAIN B/BEIJING/1/87)) [Search protein sequence]
EPEWTYPRLSCQGSTFQKALLISPHRFGEARGNSAPLIIREPFIACGPKE
CKHFALTHYAAQPGGYYNGTREDRNKLRHLISVKLGKIPTVENSIFHMAA
WSGSACHDGREWTYIGVDGPDSNALIKIKYGEAYTDTYHSYANNILRTQE
SACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPTGRVEHTEE
CTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTP
RPDDGSITGPCESNGDKGRGGIKGGFVHQRMASKIGRWYSRTMSKTERMG
MELYVRYDGDPWTDSDALAHSGVMVSMKEPGWYSFGFEIKDKKCDVPCIG
IEMVHDGGKKTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
3D structure
PDB1a4q Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D148 E275 R291 R373 Y408
Catalytic site (residue number reindexed from 1) D73 E200 R216 R298 Y333
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CA A D292 T296 D323 G343 G345 D217 T221 D248 G268 G270
BS02 DPC A R115 E116 D148 W176 I220 R222 A244 E274 E275 R291 N293 R373 Y408 R40 E41 D73 W101 I145 R147 A169 E199 E200 R216 N218 R298 Y333 MOAD: ic50=3.6uM
PDBbind-CN: -logKd/Ki=5.44,IC50=3.6uM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1a4q, PDBe:1a4q, PDBj:1a4q
PDBsum1a4q
PubMed9526556
UniProtP27907|NRAM_INBBE Neuraminidase (Gene Name=NA)

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