Structure of PDB 1a4e Chain A

Receptor sequence
>1a4eA (length=488) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DVREDRVVTNSTGNPINEPFVTQRIGEHGPLLLQDYNLIDSLAHFNRENI
PQRNPHAHGSGAFGYFEVTDDITDICGSAMFSKIGKRTKCLTRFSTVGGD
KGSADTVRDPRGFATKFYTEEGNLDWVYNNTPVFFIRDPSKFPHFIHTQK
RNPQTNLRDADMFWDFLTTPENQVAIHQVMILFSDRGTPANYRSMHGYSG
HTYKWSNKNGDWHYVQVHIKTDQGIKNLTIEEATKIAGSNPDYCQQDLFE
AIQNGNYPSWTVYIQTMTERDAKKLPFSVFDLTKVWPQGQFPLRRVGKIV
LNENPLNFFAQVEQAAFAPSTTVPYQEASADPVLQARLFSYADAHRYRLG
PNFHQIPVNCPYASKFFNPAIRDGPMNVNGNFGSEPTYLANDKSYTYIQQ
DRPIQQHQEVWNGPAIPYHWATSPGDVDFVQARNLYRVLGKQPGQQKNLA
YNIGIHVEGACPQIQQRVYDMFARVDKGLSEAIKKVAE
3D structure
PDB1a4e Structure of catalase-A from Saccharomyces cerevisiae.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H70 N143 A332
Catalytic site (residue number reindexed from 1) H56 N129 A318
Enzyme Commision number 1.11.1.6: catalase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AZI A H70 F148 F156 H56 F134 F142
BS02 HEM A R67 N68 P69 H70 R107 V141 N143 F148 F156 F331 V347 R351 S354 Y355 H359 R362 R53 N54 P55 H56 R93 V127 N129 F134 F142 F317 V333 R337 S340 Y341 H345 R348
Gene Ontology
Molecular Function
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0006979 response to oxidative stress
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix

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Cellular Component
External links
PDB RCSB:1a4e, PDBe:1a4e, PDBj:1a4e
PDBsum1a4e
PubMed9931255
UniProtP15202|CATA_YEAST Peroxisomal catalase A (Gene Name=CTA1)

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