Structure of PDB 1a3w Chain A

Receptor sequence
>1a3wA (length=492) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SRLERLTSLSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGS
YEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPN
HEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLE
VVDTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVH
MVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTD
GVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNP
RPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQA
IAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTP
RLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEA
RINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV
3D structure
PDB1a3w The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R49 R91 K240 T298
Catalytic site (residue number reindexed from 1) R43 R85 K232 T290
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGA A E242 A263 R264 G265 D266 T298 E234 A255 R256 G257 D258 T290
BS02 FBP A L401 S402 T403 S404 T406 T407 W452 R459 G484 G490 H491 L393 S394 T395 S396 T398 T399 W444 R451 G476 G482 H483
BS03 MN A E242 D266 E234 D258
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0032787 monocarboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a3w, PDBe:1a3w, PDBj:1a3w
PDBsum1a3w
PubMed9519410
UniProtP00549|KPYK1_YEAST Pyruvate kinase 1 (Gene Name=CDC19)

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