Structure of PDB 1a38 Chain A

Receptor sequence
>1a38A (length=216) Species: 9913 (Bos taurus) [Search protein sequence]
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKN
VVGARRSSWRVVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFL
IPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEI
SKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAESYK
DSTLIMQLLRDNLTLW
3D structure
PDB1a38 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
ChainA
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K49 R60 K120 L220 K49 R60 K115 L208
Gene Ontology
Molecular Function
GO:0050815 phosphoserine residue binding
GO:0140311 protein sequestering activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0042470 melanosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a38, PDBe:1a38, PDBj:1a38
PDBsum1a38
PubMed9632691
UniProtP63103|1433Z_BOVIN 14-3-3 protein zeta/delta (Gene Name=YWHAZ)

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