Structure of PDB 1a37 Chain A

Receptor sequence
>1a37A (length=195) Species: 9913 (Bos taurus) [Search protein sequence]
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKN
VVGARRSSWRVVSSIEQEKKQQMAREYREKIETELRDICNDVLSLLEKFL
IPNAAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISK
IRLGLALNFSVFYYACSLAKTAFDEAIADDSTLIMQLLRDNLTLW
3D structure
PDB1a37 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K49 R56 R127 Y128 L172 N173 K49 R56 R120 Y121 L157 N158
Gene Ontology
Molecular Function
GO:0050815 phosphoserine residue binding
GO:0140311 protein sequestering activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0042470 melanosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a37, PDBe:1a37, PDBj:1a37
PDBsum1a37
PubMed9632691
UniProtP63103|1433Z_BOVIN 14-3-3 protein zeta/delta (Gene Name=YWHAZ)

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