Structure of PDB 1a29 Chain A

Receptor sequence

>1a29A (length=144) Species: 9913 (Bos taurus)

QLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMI
NEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISA
AELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT

3D structure

• PDB: 1a29 Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies.
• Chain: A
• Resolution: 2.74 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): V35
• Catalytic site (residue number reindexed from 1): V33

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D20 D22 D24 T26 E31	D18 D20 D22 T24 E29
BS02	CA	A	D56 D58 N60 T62 E67	D54 D56 N58 T60 E65
BS03	CA	A	D93 D95 N97 Y99 E104	D91 D93 N95 Y97 E102
BS04	CA	A	D129 D131 D133 Q135 E140	D127 D129 D131 Q133 E138
BS05	TFP	A	L105 M124 E127 F141 M144	L103 M122 E125 F139 M142	BindingDB: Kd=5000nM
BS06	TFP	A	E11 E14 A15 E114 L116 E120 E123	E9 E12 A13 E112 L114 E118 E121	BindingDB: Kd=5000nM

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0019904 protein domain specific binding
• GO:0046872 metal ion binding

Biological Process

• GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
• GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
• GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component

• GO:0000922 spindle pole
• GO:0005737 cytoplasm
• GO:0005819 spindle
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1a29, PDBe:1a29, PDBj:1a29
• PDBsum: 1a29
• PubMed: 9799490
• UniProt: P62157|CALM_BOVIN Calmodulin (Gene Name=CALM)