Structure of PDB 1a1v Chain A

Receptor sequence
>1a1vA (length=432) Species: 11108 (Hepatitis C virus (isolate H)) [Search protein sequence]
PPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFG
AYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIIC
DECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEV
ALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAV
AYYRGLDVSVIPTSGDVVVVATDALFTGDFDSVIDCNTCVTQTVDFSLDP
TFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLC
ECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHI
DAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTL
HGPTPLLYRLGAVQNEVTLTHPITKYIMTCMS
3D structure
PDB1a1v Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A P230 V232 G255 T269 G271 K272 H369 S370 K371 Y392 R393 T411 A413 V432 Q434 T448 W501 Y502 P41 V43 G66 T80 G82 K83 H180 S181 K182 Y203 R204 T222 A224 V240 Q242 T256 W309 Y310
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:1a1v, PDBe:1a1v, PDBj:1a1v
PDBsum1a1v
PubMed9493270
UniProtP27958|POLG_HCV77 Genome polyprotein

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