Structure of PDB 1a16 Chain A

Receptor sequence
>1a16A (length=439) Species: 562 (Escherichia coli) [Search protein sequence]
SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSEYPYRQNSDFW
YFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPE
KLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADVIVNSLEKLRKG
SRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAMEK
CRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTENECEM
RDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETSL
RLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMHG
LSHWLGLDVHDVGVYGQDRSRILEPGMVLTVEPGLYIAPDAEVPEQYRGI
GIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ
3D structure
PDB1a16 Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D38 H243 D260 D271 H350 H354 H361 E383 Y387 R404 E406
Catalytic site (residue number reindexed from 1) D38 H242 D259 D270 H349 H353 H360 E382 Y386 R403 E405
Enzyme Commision number 3.4.11.9: Xaa-Pro aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO A H243 H350 E383 R404 H242 H349 E382 R403
BS02 LEU A G351 H361 R370 G350 H360 R369
BS03 MN A D271 H354 T381 E383 E406 D270 H353 T380 E382 E405
BS04 MN A Y229 D260 D271 E406 Y228 D259 D270 E405
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1a16, PDBe:1a16, PDBj:1a16
PDBsum1a16
PubMed9520390
UniProtP15034|AMPP_ECOLI Xaa-Pro aminopeptidase (Gene Name=pepP)

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