Structure of PDB 1a0c Chain A

Receptor sequence

>1a0cA (length=437) Species: 33950 (Thermoanaerobacterium thermosulfurigenes)

NKYFENVSKIKYEGPKSNNPYSFKFYNPEEVIDGKTMEEHLRFSIAYWHT
FTADGTDQFGKATMQRPWNHYTDPMDIAKARVEAAFEFFDKINAPYFCFH
DRDIAPEGDTLRETNKNLDTIVAMIKDYLKTSKTKVLWGTANLFSNPRFV
HGASTSCNADVFAYSAAQVKKALEITKELGGENYVFWGGREGYETLLNTD
MEFELDNFARFLHMAVDYAKEIGFEGQFLIEPKPKEPTKHQYDFDVANVL
AFLRKYDLDKYFKVNIEANHATLAFHDFQHELRYARINGVLGSIDANTGD
MLLGWDTDQFPTDIRMTTLAMYEVIKMGGFDKGGLNFDAKVRRASFEPED
LFLGHIAGMDAFAKGFKVAYKLVKDRVFDKFIEERYASYKDGIGADIVSG
KADFRSLEKYALERSQIVNKSGRQELLESILNQYLFA

3D structure

• PDB: 1a0c Catalytic Mechanism of Xylose (Glucose) Isomerase from Clostridium Thermosulfurogenes. Characterization of the Structural Gene and Function of Active Site Histidine
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H100 D103 W138 E231 K233 E267 H270 D295 D306 D308 D338
• Catalytic site (residue number reindexed from 1): H100 D103 W138 E231 K233 E267 H270 D295 D306 D308 D338
• Enzyme Commision number: 5.3.1.5: xylose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO	A	E231 E267 D295 D338	E231 E267 D295 D338
BS02	CO	A	E267 H270 D306 D308	E267 H270 D306 D308

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0009045 xylose isomerase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0042732 D-xylose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1a0c, PDBe:1a0c, PDBj:1a0c
• PDBsum: 1a0c
• UniProt: P19148|XYLA_THETU Xylose isomerase (Gene Name=xylA)