Structure of PDB 117e Chain A

Receptor sequence
>117eA (length=282) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TYTTRQIGAKNTLEYKVYIEKDGKPVSAFHDIPLYADKENNIFNMVVEIP
RWTNAKLEITKEETLNPIIQDTKKGKLRFVRNCFPHHGYIHNYGAFPQTW
EDPNVSHPETKAVGDNEPIDVLEIGETIAYTGQVKQVKALGIMALLDEGE
TDWKVIAIDINDPLAPKLNDIEDVEKYFPGLLRATNEWFRIYKIPDGKPE
NQFAFSGEAKNKKYALDIIKETHDSWKQLIAGKSSDSKGIDLTNVTLPDT
PTYSKAASDAIPPASLKADAPIDKSIDKWFFI
3D structure
PDB117e The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D115 E117 D120 D152 D115 E117 D120 D152
BS02 MN A E117 D120 E117 D120
BS03 MN A D147 D152 D147 D152
BS04 PO4 A K56 R78 D147 Y192 K193 K56 R78 D147 Y192 K193
BS05 PO4 A K56 Y93 E117 D120 K56 Y93 E117 D120
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006796 phosphate-containing compound metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:117e, PDBe:117e, PDBj:117e
PDBsum117e
PubMed9878371
UniProtP00817|IPYR_YEAST Inorganic pyrophosphatase (Gene Name=IPP1)

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