/var/www/html/BioLiP/script/receptor1 /var/www/html/BioLiP/output/7yl0A.pdb.gz -
ATOM 1 N LYS R 1 75.893 134.179 141.886 1.00186.14 N
ATOM 2 CA LYS R 1 76.961 133.586 141.096 1.00186.14 C
ATOM 3 C LYS R 1 77.243 132.153 141.530 1.00186.14 C
ATOM 4 O LYS R 1 76.634 131.229 141.022 1.00186.14 O
ATOM 5 CB LYS R 1 78.231 134.428 141.184 1.00186.14 C
ATOM 6 CG LYS R 1 78.100 135.790 140.524 1.00186.14 C
ATOM 7 CD LYS R 1 79.440 136.496 140.422 1.00186.14 C
ATOM 8 CE LYS R 1 79.315 137.778 139.618 1.00186.14 C
ATOM 9 NZ LYS R 1 80.611 138.503 139.514 1.00186.14 N
ATOM 10 N CYS R 2 78.165 132.002 142.465 1.00190.10 N
ATOM 11 CA CYS R 2 78.566 130.676 142.887 1.00190.10 C
ATOM 12 C CYS R 2 77.740 130.224 144.123 1.00190.10 C
ATOM 13 O CYS R 2 78.304 130.071 145.205 1.00190.10 O
ATOM 14 CB CYS R 2 80.117 130.703 143.068 1.00190.10 C
ATOM 15 SG CYS R 2 81.076 131.714 141.824 1.00190.10 S
ATOM 16 N ASN R 3 76.417 130.001 143.972 1.00192.23 N
ATOM 17 CA ASN R 3 75.562 129.632 145.075 1.00192.23 C
ATOM 18 C ASN R 3 75.965 128.307 145.654 1.00192.23 C
ATOM 19 O ASN R 3 76.017 128.209 146.851 1.00192.23 O
ATOM 20 CB ASN R 3 74.104 129.551 144.618 1.00192.23 C
ATOM 21 CG ASN R 3 73.502 130.912 144.321 1.00192.23 C
ATOM 22 OD1 ASN R 3 73.961 131.940 144.819 1.00192.23 O
ATOM 23 ND2 ASN R 3 72.463 130.922 143.498 1.00192.23 N
ATOM 24 N THR R 4 76.316 127.312 144.836 1.00191.05 N
ATOM 25 CA THR R 4 76.565 125.962 145.348 1.00191.05 C
ATOM 26 C THR R 4 77.969 125.547 145.811 1.00191.05 C
ATOM 27 O THR R 4 78.145 125.292 147.004 1.00191.05 O
ATOM 28 CB THR R 4 76.063 124.904 144.350 1.00 30.00 C
ATOM 29 OG1 THR R 4 74.649 125.057 144.158 1.00 30.00 O
ATOM 30 CG2 THR R 4 76.352 123.500 144.860 1.00 30.00 C
ATOM 31 N ALA R 5 78.971 125.504 144.930 1.00184.18 N
ATOM 32 CA ALA R 5 80.281 125.002 145.393 1.00184.18 C
ATOM 33 C ALA R 5 81.580 125.364 144.691 1.00184.18 C
ATOM 34 O ALA R 5 81.570 125.670 143.499 1.00184.18 O
ATOM 35 CB ALA R 5 80.215 123.485 145.526 1.00184.18 C
ATOM 36 N THR R 6 82.683 125.381 145.437 1.00176.83 N
ATOM 37 CA THR R 6 84.030 125.544 144.869 1.00176.83 C
ATOM 38 C THR R 6 84.310 126.674 143.873 1.00176.83 C
ATOM 39 O THR R 6 84.885 126.423 142.814 1.00176.83 O
ATOM 40 CB THR R 6 84.517 124.219 144.241 1.00176.83 C
ATOM 41 OG1 THR R 6 84.221 123.131 145.125 1.00176.83 O
ATOM 42 CG2 THR R 6 86.018 124.266 143.985 1.00176.83 C
ATOM 43 N CYS R 7 83.914 127.901 144.180 1.00173.53 N
ATOM 44 CA CYS R 7 84.162 128.984 143.247 1.00173.53 C
ATOM 45 C CYS R 7 85.255 129.878 143.790 1.00173.53 C
ATOM 46 O CYS R 7 85.109 130.460 144.865 1.00173.53 O
ATOM 47 CB CYS R 7 82.886 129.793 143.014 1.00173.53 C
ATOM 48 SG CYS R 7 83.086 131.195 141.889 1.00173.53 S
ATOM 49 N ALA R 8 86.356 129.995 143.053 1.00151.59 N
ATOM 50 CA ALA R 8 87.411 130.878 143.517 1.00151.59 C
ATOM 51 C ALA R 8 87.598 132.037 142.559 1.00151.59 C
ATOM 52 O ALA R 8 87.428 131.863 141.353 1.00151.59 O
ATOM 53 CB ALA R 8 88.703 130.108 143.653 1.00151.59 C
ATOM 54 N THR R 9 87.944 133.205 143.082 1.00140.87 N
ATOM 55 CA THR R 9 88.116 134.388 142.249 1.00140.87 C
ATOM 56 C THR R 9 89.227 135.277 142.720 1.00140.87 C
ATOM 57 O THR R 9 89.236 135.696 143.871 1.00140.87 O
ATOM 58 CB THR R 9 86.853 135.264 142.270 1.00140.87 C
ATOM 59 OG1 THR R 9 85.746 134.513 141.752 1.00140.87 O
ATOM 60 CG2 THR R 9 87.043 136.518 141.431 1.00140.87 C
ATOM 61 N GLN R 10 90.167 135.584 141.843 1.00127.98 N
ATOM 62 CA GLN R 10 91.194 136.539 142.208 1.00127.98 C
ATOM 63 C GLN R 10 90.880 137.767 141.389 1.00127.98 C
ATOM 64 O GLN R 10 90.759 137.692 140.168 1.00127.98 O
ATOM 65 CB GLN R 10 92.589 136.016 141.870 1.00127.98 C
ATOM 66 CG GLN R 10 93.707 137.007 142.132 1.00127.98 C
ATOM 67 CD GLN R 10 95.067 136.347 142.141 1.00127.98 C
ATOM 68 OE1 GLN R 10 95.175 135.127 142.254 1.00127.98 O
ATOM 69 NE2 GLN R 10 96.118 137.150 142.028 1.00127.98 N
ATOM 70 N ARG R 11 90.736 138.905 142.053 1.00126.76 N
ATOM 71 CA ARG R 11 90.388 140.139 141.373 1.00126.76 C
ATOM 72 C ARG R 11 91.566 141.085 141.494 1.00126.76 C
ATOM 73 O ARG R 11 91.916 141.471 142.600 1.00126.76 O
ATOM 74 CB ARG R 11 89.161 140.705 142.066 1.00126.76 C
ATOM 75 CG ARG R 11 88.610 142.009 141.524 1.00126.76 C
ATOM 76 CD ARG R 11 87.398 142.403 142.352 1.00126.76 C
ATOM 77 NE ARG R 11 86.880 143.726 142.022 1.00126.76 N
ATOM 78 CZ ARG R 11 85.837 144.284 142.629 1.00126.76 C
ATOM 79 NH1 ARG R 11 85.205 143.630 143.594 1.00126.76 N
ATOM 80 NH2 ARG R 11 85.424 145.493 142.275 1.00126.76 N
ATOM 81 N LEU R 12 92.218 141.384 140.385 1.00115.44 N
ATOM 82 CA LEU R 12 93.339 142.288 140.462 1.00115.44 C
ATOM 83 C LEU R 12 93.167 143.486 139.554 1.00115.44 C
ATOM 84 O LEU R 12 93.049 143.353 138.335 1.00115.44 O
ATOM 85 CB LEU R 12 94.640 141.555 140.122 1.00115.44 C
ATOM 86 CG LEU R 12 95.943 142.336 140.302 1.00115.44 C
ATOM 87 CD1 LEU R 12 97.147 141.422 140.128 1.00115.44 C
ATOM 88 CD2 LEU R 12 96.015 143.512 139.339 1.00115.44 C
ATOM 89 N ALA R 13 93.157 144.661 140.163 1.00114.35 N
ATOM 90 CA ALA R 13 93.110 145.905 139.405 1.00114.35 C
ATOM 91 C ALA R 13 94.382 146.680 139.691 1.00114.35 C
ATOM 92 O ALA R 13 94.573 147.176 140.806 1.00114.35 O
ATOM 93 CB ALA R 13 91.876 146.730 139.782 1.00114.35 C
ATOM 94 N ASN R 14 95.251 146.767 138.685 1.00113.22 N
ATOM 95 CA ASN R 14 96.514 147.469 138.846 1.00113.22 C
ATOM 96 C ASN R 14 96.577 148.688 137.961 1.00113.22 C
ATOM 97 O ASN R 14 96.366 148.591 136.763 1.00113.22 O
ATOM 98 CB ASN R 14 97.688 146.540 138.559 1.00113.22 C
ATOM 99 CG ASN R 14 99.030 147.175 138.859 1.00113.22 C
ATOM 100 OD1 ASN R 14 100.035 146.844 138.234 1.00113.22 O
ATOM 101 ND2 ASN R 14 99.054 148.088 139.818 1.00113.22 N
ATOM 102 N PHE R 15 96.849 149.839 138.542 1.00111.78 N
ATOM 103 CA PHE R 15 96.959 151.100 137.824 1.00111.78 C
ATOM 104 C PHE R 15 98.275 151.749 138.209 1.00111.78 C
ATOM 105 O PHE R 15 98.546 151.951 139.395 1.00111.78 O
ATOM 106 CB PHE R 15 95.793 152.040 138.153 1.00111.78 C
ATOM 107 CG PHE R 15 94.441 151.384 138.092 1.00111.78 C
ATOM 108 CD1 PHE R 15 93.976 150.620 139.150 1.00111.78 C
ATOM 109 CD2 PHE R 15 93.616 151.558 136.993 1.00111.78 C
ATOM 110 CE1 PHE R 15 92.731 150.024 139.102 1.00111.78 C
ATOM 111 CE2 PHE R 15 92.365 150.966 136.946 1.00111.78 C
ATOM 112 CZ PHE R 15 91.925 150.198 138.001 1.00111.78 C
ATOM 113 N LEU R 16 99.080 152.075 137.204 1.00 96.46 N
ATOM 114 CA LEU R 16 100.381 152.687 137.434 1.00 96.46 C
ATOM 115 C LEU R 16 100.447 153.964 136.613 1.00 96.46 C
ATOM 116 O LEU R 16 100.079 153.960 135.444 1.00 96.46 O
ATOM 117 CB LEU R 16 101.467 151.727 136.964 1.00 96.46 C
ATOM 118 CG LEU R 16 102.902 151.867 137.460 1.00 96.46 C
ATOM 119 CD1 LEU R 16 103.545 150.492 137.408 1.00 96.46 C
ATOM 120 CD2 LEU R 16 103.680 152.843 136.592 1.00 96.46 C
ATOM 121 N VAL R 17 100.908 155.055 137.216 1.00 93.92 N
ATOM 122 CA VAL R 17 101.016 156.325 136.513 1.00 93.92 C
ATOM 123 C VAL R 17 102.395 156.911 136.719 1.00 93.92 C
ATOM 124 O VAL R 17 102.641 157.545 137.725 1.00 93.92 O
ATOM 125 CB VAL R 17 100.018 157.340 137.077 1.00 93.92 C
ATOM 126 CG1 VAL R 17 100.047 158.637 136.279 1.00 93.92 C
ATOM 127 CG2 VAL R 17 98.611 156.769 137.125 1.00 93.92 C
ATOM 128 N HIS R 18 103.299 156.714 135.777 1.00 93.10 N
ATOM 129 CA HIS R 18 104.607 157.312 135.896 1.00 93.10 C
ATOM 130 C HIS R 18 104.568 158.545 135.064 1.00 93.10 C
ATOM 131 O HIS R 18 104.322 158.479 133.876 1.00 93.10 O
ATOM 132 CB HIS R 18 105.677 156.380 135.350 1.00 93.10 C
ATOM 133 CG HIS R 18 107.056 156.961 135.351 1.00 93.10 C
ATOM 134 ND1 HIS R 18 108.011 156.604 136.275 1.00 93.10 N
ATOM 135 CD2 HIS R 18 107.648 157.863 134.530 1.00 93.10 C
ATOM 136 CE1 HIS R 18 109.128 157.262 136.030 1.00 93.10 C
ATOM 137 NE2 HIS R 18 108.934 158.035 134.977 1.00 93.10 N
ATOM 138 N SER R 19 104.818 159.686 135.665 1.00 95.21 N
ATOM 139 CA SER R 19 104.839 160.912 134.915 1.00 95.21 C
ATOM 140 C SER R 19 106.046 161.708 135.279 1.00 95.21 C
ATOM 141 O SER R 19 106.298 161.935 136.446 1.00 95.21 O
ATOM 142 CB SER R 19 103.602 161.730 135.212 1.00 95.21 C
ATOM 143 OG SER R 19 103.704 163.016 134.631 1.00 95.21 O
ATOM 144 N SER R 20 106.807 162.140 134.293 1.00 97.57 N
ATOM 145 CA SER R 20 107.921 163.002 134.598 1.00 97.57 C
ATOM 146 C SER R 20 107.741 164.259 133.815 1.00 97.57 C
ATOM 147 O SER R 20 107.714 164.219 132.601 1.00 97.57 O
ATOM 148 CB SER R 20 109.231 162.347 134.199 1.00 97.57 C
ATOM 149 OG SER R 20 110.289 163.286 134.234 1.00 97.57 O
ATOM 150 N ASN R 21 107.593 165.397 134.471 1.00 97.79 N
ATOM 151 CA ASN R 21 107.524 166.659 133.758 1.00 97.79 C
ATOM 152 C ASN R 21 108.802 167.354 134.100 1.00 97.79 C
ATOM 153 O ASN R 21 108.957 167.823 135.214 1.00 97.79 O
ATOM 154 CB ASN R 21 106.333 167.483 134.206 1.00 97.79 C
ATOM 155 CG ASN R 21 105.011 166.803 133.927 1.00 97.79 C
ATOM 156 OD1 ASN R 21 104.004 167.112 134.559 1.00 97.79 O
ATOM 157 ND2 ASN R 21 105.004 165.876 132.979 1.00 97.79 N
ATOM 158 N ASN R 22 109.736 167.393 133.172 1.00 96.40 N
ATOM 159 CA ASN R 22 111.030 167.976 133.455 1.00 96.40 C
ATOM 160 C ASN R 22 111.123 169.366 132.882 1.00 96.40 C
ATOM 161 O ASN R 22 111.495 169.531 131.730 1.00 96.40 O
ATOM 162 CB ASN R 22 112.105 167.069 132.873 1.00 96.40 C
ATOM 163 CG ASN R 22 113.459 167.722 132.791 1.00 96.40 C
ATOM 164 OD1 ASN R 22 114.166 167.562 131.805 1.00 96.40 O
ATOM 165 ND2 ASN R 22 113.818 168.471 133.803 1.00 96.40 N
ATOM 166 N PHE R 23 110.768 170.384 133.651 1.00100.58 N
ATOM 167 CA PHE R 23 110.963 171.724 133.117 1.00100.58 C
ATOM 168 C PHE R 23 112.354 172.176 133.471 1.00100.58 C
ATOM 169 O PHE R 23 112.503 173.192 134.134 1.00100.58 O
ATOM 170 CB PHE R 23 110.009 172.723 133.760 1.00100.58 C
ATOM 171 CG PHE R 23 108.560 172.471 133.488 1.00100.58 C
ATOM 172 CD1 PHE R 23 107.880 171.456 134.138 1.00100.58 C
ATOM 173 CD2 PHE R 23 107.862 173.284 132.620 1.00100.58 C
ATOM 174 CE1 PHE R 23 106.543 171.234 133.898 1.00100.58 C
ATOM 175 CE2 PHE R 23 106.519 173.073 132.377 1.00100.58 C
ATOM 176 CZ PHE R 23 105.858 172.044 133.016 1.00100.58 C
ATOM 177 N GLY R 24 113.380 171.474 133.032 1.00101.55 N
ATOM 178 CA GLY R 24 114.717 171.829 133.462 1.00101.55 C
ATOM 179 C GLY R 24 115.746 170.848 132.975 1.00101.55 C
ATOM 180 O GLY R 24 115.489 170.095 132.048 1.00101.55 O
ATOM 181 N ALA R 25 116.910 170.827 133.603 1.00 99.93 N
ATOM 182 CA ALA R 25 117.979 169.967 133.125 1.00 99.93 C
ATOM 183 C ALA R 25 118.182 168.719 133.939 1.00 99.93 C
ATOM 184 O ALA R 25 118.374 168.789 135.136 1.00 99.93 O
ATOM 185 CB ALA R 25 119.271 170.748 133.071 1.00 99.93 C
ATOM 186 N ILE R 26 118.139 167.564 133.286 1.00 94.15 N
ATOM 187 CA ILE R 26 118.407 166.302 133.952 1.00 94.15 C
ATOM 188 C ILE R 26 119.626 165.786 133.247 1.00 94.15 C
ATOM 189 O ILE R 26 119.652 165.747 132.032 1.00 94.15 O
ATOM 190 CB ILE R 26 117.315 165.258 133.693 1.00 94.15 C
ATOM 191 CG1 ILE R 26 115.961 165.725 134.199 1.00 94.15 C
ATOM 192 CG2 ILE R 26 117.673 163.922 134.326 1.00 94.15 C
ATOM 193 CD1 ILE R 26 114.906 164.648 134.125 1.00 94.15 C
ATOM 194 N LEU R 27 120.651 165.397 133.977 1.00 96.67 N
ATOM 195 CA LEU R 27 121.809 164.814 133.345 1.00 96.67 C
ATOM 196 C LEU R 27 122.024 163.482 133.998 1.00 96.67 C
ATOM 197 O LEU R 27 122.000 163.380 135.213 1.00 96.67 O
ATOM 198 CB LEU R 27 123.019 165.716 133.548 1.00 96.67 C
ATOM 199 CG LEU R 27 124.372 165.428 132.891 1.00 96.67 C
ATOM 200 CD1 LEU R 27 125.137 166.729 132.708 1.00 96.67 C
ATOM 201 CD2 LEU R 27 125.214 164.423 133.661 1.00 96.67 C
ATOM 202 N SER R 28 122.277 162.454 133.206 1.00 94.85 N
ATOM 203 CA SER R 28 122.472 161.128 133.752 1.00 94.85 C
ATOM 204 C SER R 28 123.536 160.353 133.031 1.00 94.85 C
ATOM 205 O SER R 28 123.607 160.390 131.818 1.00 94.85 O
ATOM 206 CB SER R 28 121.177 160.341 133.694 1.00 94.85 C
ATOM 207 OG SER R 28 121.401 158.988 134.038 1.00 94.85 O
ATOM 208 N SER R 29 124.366 159.632 133.763 1.00 93.36 N
ATOM 209 CA SER R 29 125.382 158.811 133.136 1.00 93.36 C
ATOM 210 C SER R 29 125.393 157.445 133.757 1.00 93.36 C
ATOM 211 O SER R 29 125.509 157.324 134.960 1.00 93.36 O
ATOM 212 CB SER R 29 126.753 159.442 133.295 1.00 93.36 C
ATOM 213 OG SER R 29 127.764 158.546 132.875 1.00 93.36 O
ATOM 214 N THR R 30 125.280 156.404 132.950 1.00 87.13 N
ATOM 215 CA THR R 30 125.366 155.064 133.490 1.00 87.13 C
ATOM 216 C THR R 30 126.554 154.417 132.835 1.00 87.13 C
ATOM 217 O THR R 30 126.562 154.248 131.633 1.00 87.13 O
ATOM 218 CB THR R 30 124.111 154.258 133.160 1.00 87.13 C
ATOM 219 OG1 THR R 30 122.951 155.012 133.528 1.00 87.13 O
ATOM 220 CG2 THR R 30 124.110 152.939 133.907 1.00 87.13 C
ATOM 221 N ASN R 31 127.579 154.072 133.594 1.00 82.15 N
ATOM 222 CA ASN R 31 128.767 153.501 133.002 1.00 82.15 C
ATOM 223 C ASN R 31 128.973 152.109 133.545 1.00 82.15 C
ATOM 224 O ASN R 31 129.723 151.923 134.485 1.00 82.15 O
ATOM 225 CB ASN R 31 130.007 154.332 133.304 1.00 82.15 C
ATOM 226 CG ASN R 31 129.950 155.726 132.723 1.00 82.15 C
ATOM 227 OD1 ASN R 31 130.720 156.597 133.121 1.00 82.15 O
ATOM 228 ND2 ASN R 31 129.053 155.949 131.776 1.00 82.15 N
ATOM 229 N VAL R 32 128.331 151.119 132.949 1.00 77.91 N
ATOM 230 CA VAL R 32 128.443 149.773 133.475 1.00 77.91 C
ATOM 231 C VAL R 32 129.525 148.979 132.779 1.00 77.91 C
ATOM 232 O VAL R 32 129.420 148.694 131.602 1.00 77.91 O
ATOM 233 CB VAL R 32 127.169 148.995 133.232 1.00 77.91 C
ATOM 234 CG1 VAL R 32 127.385 147.544 133.615 1.00 77.91 C
ATOM 235 CG2 VAL R 32 126.008 149.625 133.982 1.00 77.91 C
ATOM 236 N GLY R 33 130.559 148.594 133.523 1.00 75.92 N
ATOM 237 CA GLY R 33 131.637 147.802 132.952 1.00 75.92 C
ATOM 238 C GLY R 33 132.607 148.648 132.162 1.00 75.92 C
ATOM 239 O GLY R 33 133.633 148.152 131.696 1.00 75.92 O
ATOM 240 N SER R 34 132.293 149.928 132.009 1.00 76.59 N
ATOM 241 CA SER R 34 133.145 150.813 131.268 1.00 76.59 C
ATOM 242 C SER R 34 134.390 151.084 132.028 1.00 76.59 C
ATOM 243 O SER R 34 134.421 150.875 133.191 1.00 76.59 O
ATOM 244 CB SER R 34 132.417 152.114 131.029 1.00 76.59 C
ATOM 245 OG SER R 34 133.261 153.058 130.399 1.00 76.59 O
ATOM 246 N ASN R 35 135.455 151.496 131.386 1.00 79.18 N
ATOM 247 CA ASN R 35 136.629 151.877 132.128 1.00 79.18 C
ATOM 248 C ASN R 35 137.235 153.057 131.445 1.00 79.18 C
ATOM 249 O ASN R 35 137.086 153.206 130.260 1.00 79.18 O
ATOM 250 CB ASN R 35 137.636 150.744 132.176 1.00 79.18 C
ATOM 251 CG ASN R 35 137.081 149.491 132.809 1.00 79.18 C
ATOM 252 OD1 ASN R 35 136.851 148.490 132.146 1.00 79.18 O
ATOM 253 ND2 ASN R 35 136.837 149.552 134.097 1.00 79.18 N
ATOM 254 N THR R 36 137.916 153.912 132.171 1.00 87.70 N
ATOM 255 CA THR R 36 138.600 155.012 131.538 1.00 87.70 C
ATOM 256 C THR R 36 140.051 154.899 131.887 1.00 87.70 C
ATOM 257 O THR R 36 140.391 154.796 133.051 1.00 87.70 O
ATOM 258 CB THR R 36 138.073 156.351 132.039 1.00 87.70 C
ATOM 259 OG1 THR R 36 136.650 156.382 131.905 1.00 87.70 O
ATOM 260 CG2 THR R 36 138.676 157.493 131.249 1.00 87.70 C
ATOM 261 N TYR R 37 141.092 154.702 131.307 1.00 20.00 N
ATOM 262 CA TYR R 37 142.560 154.662 131.314 1.00 20.00 C
ATOM 263 C TYR R 37 143.101 156.025 130.966 1.00 20.00 C
ATOM 264 O TYR R 37 142.469 156.760 130.238 1.00 20.00 O
ATOM 265 CB TYR R 37 143.046 153.640 130.286 1.00 20.00 C
ATOM 266 CG TYR R 37 142.634 152.258 130.716 1.00 20.00 C
ATOM 267 CD1 TYR R 37 141.339 151.825 130.497 1.00 20.00 C
ATOM 268 CD2 TYR R 37 143.552 151.422 131.326 1.00 20.00 C
ATOM 269 CE1 TYR R 37 140.960 150.556 130.892 1.00 20.00 C
ATOM 270 CE2 TYR R 37 143.176 150.156 131.725 1.00 20.00 C
ATOM 271 OH TYR R 37 141.505 148.469 131.896 1.00 20.00 O
ATOM 272 CZ TYR R 37 141.877 149.718 131.507 1.00 20.00 C
ATOM 273 NXT TYR R 37 144.288 156.426 131.462 1.00 20.00 N
TER