Structure of PDB 8rm5 Chain 9

Receptor sequence
>8rm59 (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRY
MEVSGNLRDLYDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPN
EICVPMSVEFEELLKARENPSEEAQNLVEFTDEEGYGRYLDLHDCYLKYI
NLKASEKLDYITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQDYTDRV
KPLQDQNELFGKIQAEFEKKWENGTFPGWEERAQRLFSTKGKSLESLDTS
LFAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQ
ARTGEEREEEEEEPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEW
RHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKL
3D structure
PDB8rm5 Structural insights into the cross-exon to cross-intron spliceosome switch
Chain9
Resolution6.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna 9 P393 Y394 W395 P314 Y315 W316
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8rm5, PDBe:8rm5, PDBj:8rm5
PDBsum8rm5
PubMed38778104
UniProtQ12874|SF3A3_HUMAN Splicing factor 3A subunit 3 (Gene Name=SF3A3)

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