Structure of PDB 7pit Chain 9

Receptor sequence

>7pit9 (length=682) Species: 272634 (Mycoplasmoides pneumoniae M129)

TVDLINFRNFGIMAHIDAGKTTTSERILFHSGRIHKIGETHDGESVMDWM
EQEKERGITITSAATSVSWKNCSLNLIDTPGHVDFTVEVERSLRVLDGAI
AVLDAQMGVEPQTETVWRQASRYEVPRIIFVNKMDKTGANFERSVQSIQQ
RLGVKAVPIQLPIGAENDFNGIIDLIEEKVYFFDGGKEEKAEEKPIPDQF
KDQVKQMRAHLVEEVANFDDQLMADYLEGKEISIADIKRCIRKGVIGCQF
FPVLCGSAFKNKGIKLLLDAVVDFLPSPVDVPQAKAYGEDGNEVLISASD
DAPFVGLAFKVATDPFVGRLTFVRVYSGVLKSGSYVKNVRKNKKERVSRL
VKMHAQNRNEIEEIRAGDICAIIGLKDTTTGETLVDDKIDVQLEAMQFAQ
PVISLAVEPKTKADQEKMSIALSKLAEEDPTFKTFTDPETGQTIIAGMGE
LHLDILVDRMRREFKVEVNVGAPQVSFRETFNKESEVEGKYIKQSGGRGQ
YGHVKIRFEPNKDKGFEFVDKIVGGRIPREYIKPVQAGLENAMASGPLAG
YPMIDIKATLFDGSFHEVDSSEMAFKIAASLALKEAGKVCSPVLLEPIMA
IEVTVPEQYFGDTMGDISSRRGLIEGTEQRDNVQVIKAKVPLKEMFGYAT
DLRSFSQGRGNYVMQFSHYAETPKSVVNEIIA

3D structure

• PDB: 7pit Visualizing translation dynamics at atomic detail inside a bacterial cell.
• Chain: 9
• Resolution: 5.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	9	H18 I19 D20 Q55 K57 Q109 M110 F262 L454 E610 F613 M617 I627 E628 G629 T630 E631 K640 R656 S657 Q660	H15 I16 D17 Q52 K54 Q106 M107 F259 L451 E607 F610 M614 I624 E625 G626 T627 E628 K637 R653 S654 Q657
BS02	rna	9	H44 D45 F319 R349 I376 K379 S498 G499 G500 V526 G527 G528 R532 E570 E575 M576	H41 D42 F316 R346 I373 K376 S495 G496 G497 V523 G524 G525 R529 E567 E572 M573
BS03	rna	9	K493 Y494 I495 G500 R501 G502 G505 H506 S567 F568 V571	K490 Y491 I492 G497 R498 G499 G502 H503 S564 F565 V568

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0032790 ribosome disassembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7pit, PDBe:7pit, PDBj:7pit
• PDBsum: 7pit
• PubMed: 36171285
• UniProt: P75544|EFG_MYCPN Elongation factor G (Gene Name=fusA)