Structure of PDB 4wzo Chain 88

Receptor sequence

>4wzo88 (length=137) Species: 300852 (Thermus thermophilus HB8)

MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAA
RVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNYVAVVKPGRVM
FEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDEA

3D structure

• PDB: 4wzo Structural insights into the translational infidelity mechanism.
• Chain: 88
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	88	R51 R56 R60	R51 R56 R60
BS02	rna	88	P4 R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 K18 T21 K22 G24 Y26 F29 W41 Q46 A49 R56 F65 R67 F69 D71 Y74 K76 K77 V81 R82 G84 K85 G86 R101 R119 I120 H123 K124 P126 K128	P4 R5 R6 K8 Y9 K11 Q12 Q13 R14 G15 R16 K18 T21 K22 G24 Y26 F29 W41 Q46 A49 R56 F65 R67 F69 D71 Y74 K76 K77 V81 R82 G84 K85 G86 R98 R116 I117 H120 K121 P123 K125
BS03	rna	88	R16 L17 G19	R16 L17 G19
BS04	MG	88	T21 K22 R101	T21 K22 R98

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4wzo, PDBe:4wzo, PDBj:4wzo
• PDBsum: 4wzo
• PubMed: 26037619
• UniProt: P60489|RL16_THET8 Large ribosomal subunit protein uL16 (Gene Name=rplP)