Structure of PDB 8oeq Chain 8

Receptor sequence

>8oeq8 (length=121) Species: 5476 (Candida albicans)

KALKVRTSTTFRLPKTLKLTRSPKYQRKSVPHYNRLDAHKIIVAPIATET
AMKKVEDGNTLVFQVDIKSNKHQIKSAVKELYDVDALYVNTLIRPNGTKK
AYIRLTSDYDALDIANRIGYI

3D structure

• PDB: 8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
• Chain: 8
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	8	L24 T30 T31 R33 L34 P35 K36 T37 K39 L40 R42 P44 K45 Y46 R48 T71 K75 N91 K92 H93 Y109 N111 T112 L113 I114 P116 K120 K121 Y123 R125	L3 T9 T10 R12 L13 P14 K15 T16 K18 L19 R21 P23 K24 Y25 R27 T50 K54 N70 K71 H72 Y88 N90 T91 L92 I93 P95 K99 K100 Y102 R104
BS02	rna	8	P35 T37 L38 K49 H53 Y54 N55 R56 K61 K89 H93 Q94	P14 T16 L17 K28 H32 Y33 N34 R35 K40 K68 H72 Q73
BS03	MG	8	H53 Y54	H32 Y33

External links

• PDB: RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
• PDBsum: 8oeq
• UniProt: A0A8H6F6A1