Structure of PDB 7pt7 Chain 8

Receptor sequence
>7pt78 (length=402) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITK
KFASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDA
KRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGI
IHRDIKPTNFLFNLELGRGVLVDFGLAEAQMDYKSNHEQFCPCIMRNQYS
VNGVDLTKGYPKNETRRIKRANRAGTRGFRAPEVLMKCGAQSTKIDIWSV
GVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCAALHGLGFEAS
GLIWDKPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHD
DAYELKKYQEEIWSDHYWCFQVLEQCFEMDPQKRSSAEDLLKTPFFNELN
EN
3D structure
PDB7pt7 The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer.
Chain8
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide 8 T43 R282 T34 R227
BS02 ADP 8 G40 F44 V47 K76 Y123 T167 L170 V181 D182 G31 F35 V38 K67 Y114 T158 L161 V172 D173
BS03 MG 8 N168 D182 N159 D173
BS04 BEF 8 D163 N168 D182 D154 N159 D173
BS05 MG 8 D182 G184 D173 G175
BS06 ZN 8 C223 H348 C191 H293
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0001100 negative regulation of exit from mitosis
GO:0006270 DNA replication initiation
GO:0006279 premeiotic DNA replication
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0031503 protein-containing complex localization
GO:0033314 mitotic DNA replication checkpoint signaling
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0060903 positive regulation of meiosis I
GO:1902977 mitotic DNA replication preinitiation complex assembly
GO:1903343 positive regulation of meiotic DNA double-strand break formation
GO:1904968 positive regulation of spindle attachment to meiosis I kinetochore
GO:1905263 positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
GO:1905342 positive regulation of protein localization to kinetochore
GO:1905561 positive regulation of kinetochore assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005813 centrosome
GO:0031431 Dbf4-dependent protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pt7, PDBe:7pt7, PDBj:7pt7
PDBsum7pt7
PubMed35614055
UniProtP06243|CDC7_YEAST Cell division control protein 7 (Gene Name=CDC7)

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