Structure of PDB 8qrn Chain 7

Receptor sequence

>8qrn7 (length=571) Species: 9606 (Homo sapiens) [Search protein sequence]

DKVRKNKDAVRRPQADPALLTPRSPVVTIMGHVDHGKTTLLDKFRKTQVA
AVETGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVV
LVVAADDGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKVKKELLA
YDVVCEDYGGDVQAVPVSALTGDNLMALAEATVALAEMLELKADPNGPVE
GTVIESFTDKGRGLVTTAIIQRGTLRKGSVLVAGKCWAKVRLMFDENGKT
IDEAYPSMPVGITGWRDLPSAGEEILEVESEPRAREVVDWRKYEQEQEKG
QEDLKIIEEKRKEHKEAHQKAREKYGHLLWKKRSILRFLERKEQIPLKPK
EKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECELELVHFGVGDV
SANDVNLAETFDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIYRLVEDL
QEELSSRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCRVQKGQLEKQ
KKFKLTRNGHVIWKGSLTSLKHHKDDISIVKTGMDCGLSLDEDNMEFQVG
DRIVCYEEKQIQAKTSWDPGF

3D structure

PDB

8qrn GTPBP8 plays a role in mitoribosome formation in human mitochondria.

Chain

Resolution

2.98 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	7	R160 T364 D365 K366 G367 R368 G369 K383 K395 R397 L398 P438 R441 R467 H470 H474 R478 L485 W486 K487 K504 K506 S557 N559	R4 T208 D209 K210 G211 R212 G213 K227 K239 R241 L242 P282 R285 R311 H314 H318 R322 L329 W330 K331 K348 K350 S401 N403
BS02	rna	7	V634 T635 K638 V643 S675 K677 K680 G693 S695	V478 T479 K482 V487 S519 K521 K524 G537 S539
BS03	FME	7	H678 H679 D691	H522 H523 D535
BS04	GTP	7	D190 H191 G192 K193 T194 T195 I213 T214 G237 N288 K289 D291 L326	D34 H35 G36 K37 T38 T39 I57 T58 G81 N132 K133 D135 L170
BS05	MG	7	T194 T214	T38 T58

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005525	GTP binding
GO:0008135	translation factor activity, RNA binding
GO:0043024	ribosomal small subunit binding

	Biological Process
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0032790	ribosome disassembly
GO:0070124	mitochondrial translational initiation

	Cellular Component
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8qrn, PDBe:8qrn, PDBj:8qrn
PDBsum	8qrn
PubMed	38969660
UniProt	P46199\|IF2M_HUMAN Translation initiation factor IF-2, mitochondrial (Gene Name=MTIF2)

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