Structure of PDB 8p63 Chain 7

Receptor sequence
>8p637 (length=663) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
ALPSIQLPVDYNNLFNEITDFLVTFKQKGPKYMAMLQKVANRELNSVIID
LDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRAIDNNMPLPTKE
IDYKDDVLDVILNQRRLRNERMLTELFPPNLTRRYFLYFKPLSQNCARRY
RKKAISSKPLSVRQIKGDFLGQLITVRGIITRVSDVKPAVEVIAYTCDQC
GYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFMSTRASKFSAFQECKI
QELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPYTGFKA
LKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLA
KSIAPEIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVA
KSQLLKAICKISPRGVYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVL
ADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGINTTLNARTSILA
AANPLYGRYNPRLSPLDNINLPAALLSRFDILFLMLDIPSRDDDEKLAEH
VTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYVVQAYI
RLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEE
ALRLVRVSKESLY
3D structure
PDB8p63 Unwinding of a eukaryotic origin of replication visualized by cryo-EM.
Chain7
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN 7 C265 K295 C200 K230
BS02 ATP 7 I422 P462 G463 V464 A465 K466 S467 L612 I357 P397 G398 V399 A400 K401 S402 L547
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:1904931 MCM complex binding
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0033260 nuclear DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p63, PDBe:8p63, PDBj:8p63
PDBsum8p63
PubMed38760633
UniProtP38132|MCM7_YEAST DNA replication licensing factor MCM7 (Gene Name=MCM7)

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