Structure of PDB 8i0s Chain 7

Receptor sequence
>8i0s7 (length=81) Species: 9606 (Homo sapiens) [Search protein sequence]
IFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRC
VICGGPGVSDAYYCKECTIQEKDRDGCPKIV
3D structure
PDB8i0s Molecular Basis for the Activation of Human Spliceosome
Chain7
Resolution4.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN 7 C23 C26 C58 C61 C15 C18 C50 C53
BS02 ZN 7 C11 C49 C3 C41
BS03 ZN 7 I32 C33 I24 C25
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045893 positive regulation of DNA-templated transcription
GO:0048863 stem cell differentiation
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0s, PDBe:8i0s, PDBj:8i0s
PDBsum8i0s
PubMed39068178
UniProtQ7RTV0|PHF5A_HUMAN PHD finger-like domain-containing protein 5A (Gene Name=PHF5A)

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