Structure of PDB 8b9d Chain 7

Receptor sequence
>8b9d7 (length=576) Species: 9606 (Homo sapiens) [Search protein sequence]
LKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDL
DDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVY
IEHRLMMEQPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIV
TRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSG
GRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQP
GDHVSVTGIFLPILRTGLLSETYLEAHRIVKMDFYEKLAASIAPEIYGHE
DVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLA
PRSQYTTGRGSSGVGLTAAVLRTLEGGALVLADQGVCCIDEFDKMAEADR
TAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNI
QLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHDMKLMRRYIAMC
REKQPMVPESLADYITAAYVEMRREAWASTYTSARTLLAILRLSTALARL
RMVDVVEKEDVNEAIRLMEMSKDSLL
3D structure
PDB8b9d How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Chain7
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 7 R215 R420 R198 R372
BS02 ZN 7 C184 C187 C206 C167 C170 C189
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0008283 cell population proliferation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0042325 regulation of phosphorylation
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b9d, PDBe:8b9d, PDBj:8b9d
PDBsum8b9d
PubMed37506699
UniProtP33993|MCM7_HUMAN DNA replication licensing factor MCM7 (Gene Name=MCM7)

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