Structure of PDB 7zah Chain 7

Receptor sequence

>7zah7 (length=595) Species: 272844 (Pyrococcus abyssi GE5)

RIRQPIIAVLGHVDHGKTTLLDRIRKTNVAAKEAGGITQHIGATEVPIEV
VKKIAGPLIKLWKAEIKLPGLLFIDTPGHEAFTSLRARGGSLADLAVLVV
DINEGFQPQTIESIEILRKYRTPFVVAANKIDRIKGWVIEEDEPFLMNIK
KQDQRAVQELETKLWELIGKFYEFGFQANRFDRVQNFTRELAIVPISAKY
GIGIAELLVLIAGLSQRYLEEKLKIEVEGPARGTILEVREEPGLGHTIDV
IIYDGTLHKDDTIVVGGKDKAIVTKIRALLKPKPLDEIRDPRFRFDYVDE
VTAAAGVKIAAPGLEEALAGSPVIAAPTPEDVEKAKQEILEQIERVVIST
DKVGVIVKADTLGSLEALSKELQEKEIPIRKADVGNVSKTDVMEALSVKE
EEPKYGVILGFNVKVNEDAEEVAKAKDVKIFVGNVIYKLIEDYEEWVKEE
EEKKKRELLSKVTFPGVIRLYPDERYVFRRSNPAIVGIEVIEGRIKPGVT
LIKQNGQKVGVIRSIKSRDEFLQEAKKGQAVAIAIEGAIVGRHIHPGETL
YVDLSRDDAITLLKHLRDTLEDTDIKALKMIAKVKAKEDPFWRAI

3D structure

• PDB: 7zah Role of aIF5B in archaeal translation initiation.
• Chain: 7
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	7	G246 L247 K278 R280 R295 Y300 K392	G243 L244 K275 R277 R292 Y297 K389
BS02	rna	7	F481 R482 R483 S517 K519 R521 A535 A537 R545	F478 R479 R480 S514 K516 R518 A532 A534 R542
BS03	MET	7	Y479 F481 A533 V534	Y476 F478 A530 V531
BS04	GNP	7	D17 G19 K20 T21 T22 K133 D135 K202	D14 G16 K17 T18 T19 K130 D132 K199
BS05	MG	7	T21 T41	T18 T38

Gene Ontology

Molecular Function

• GO:0003743 translation initiation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006413 translational initiation

External links

• PDB: RCSB:7zah, PDBe:7zah, PDBj:7zah
• PDBsum: 7zah
• PubMed: 35694843
• UniProt: Q9UZK7|IF2P_PYRAB Probable translation initiation factor IF-2 (Gene Name=infB)