Structure of PDB 7w1y Chain 7

Receptor sequence
>7w1y7 (length=636) Species: 9606 (Homo sapiens) [Search protein sequence]
LKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDL
DDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVY
IEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREV
RADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMP
LIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRS
ITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHR
IVKMNKSEDLTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLV
GGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGS
SGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIH
EVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPA
ALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLM
RRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAI
LRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLL
3D structure
PDB7w1y The human pre-replication complex is an open complex.
Chain7
Resolution2.59 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 7 R286 K471 A472 R284 K462 A463
BS02 ATP 7 R514 R604 R505 R595
BS03 ZN 7 C184 C187 C182 C185
BS04 ATP 7 Y345 P383 G384 V385 A386 K387 S388 N489 L533 Y336 P374 G375 V376 A377 K378 S379 N480 L524
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0008283 cell population proliferation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0042325 regulation of phosphorylation
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w1y, PDBe:7w1y, PDBj:7w1y
PDBsum7w1y
PubMed36608662
UniProtP33993|MCM7_HUMAN DNA replication licensing factor MCM7 (Gene Name=MCM7)

[Back to BioLiP]