Structure of PDB 7plo Chain 7

Receptor sequence
>7plo7 (length=607) Species: 9606 (Homo sapiens) [Search protein sequence]
LKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDL
DDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVY
IEHRLMMEQRSRPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVR
GIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTN
RSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRI
AQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMDFYEKLAA
SIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKS
QLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLAD
QGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAA
NPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHIT
YVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEM
RREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLME
MSKDSLL
3D structure
PDB7plo A conserved mechanism for regulating replisome disassembly in eukaryotes.
Chain7
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 7 F285 R286 K471 F271 R272 K433
BS02 dna 7 Q287 V288 Q273 V274
BS03 ZN 7 C184 C187 C206 C170 C173 C192
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006974 DNA damage response
GO:0008283 cell population proliferation
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:0042325 regulation of phosphorylation
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7plo, PDBe:7plo, PDBj:7plo
PDBsum7plo
PubMed34700328
UniProtP33993|MCM7_HUMAN DNA replication licensing factor MCM7 (Gene Name=MCM7)

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