Structure of PDB 7nvy Chain 7

Receptor sequence

>7nvy7 (length=605) Species: 9606 (Homo sapiens) [Search protein sequence]

TKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFL
VAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPD
GIMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLR
QTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAV
LRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLG
NSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGH
TTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLG
LTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMS
PEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNV
FALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSF
DLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQ
DTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQK
VLAAT

3D structure

PDB

7nvy Structures of mammalian RNA polymerase II pre-initiation complexes.

Chain

Resolution

7.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.4: DNA 3'-5' helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	7	T417 K449 M450 F451 R472 K528 H629 G631 Y672	T302 K334 M335 F336 R357 K413 H514 G516 Y557
BS02	dna	7	S367 A368 S394 S411 M412 H415 K418 R419 S420 V565 S608 K609 V610	S252 A253 S279 S296 M297 H300 K303 R304 S305 V450 S493 K494 V495
BS03	peptide	7	Y581 E588 N595 H598	Y466 E473 N480 H483
BS04	peptide	7	R198 L199 R200 Q266 T267 V268 S269	R148 L149 R150 Q151 T152 V153 S154

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003684	damaged DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016853	isomerase activity
GO:0016887	ATP hydrolysis activity
GO:0043138	3'-5' DNA helicase activity
GO:1990841	promoter-specific chromatin binding

	Biological Process
GO:0000717	nucleotide-excision repair, DNA duplex unwinding
GO:0001666	response to hypoxia
GO:0006265	DNA topological change
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006366	transcription by RNA polymerase II
GO:0006367	transcription initiation at RNA polymerase II promoter
GO:0006368	transcription elongation by RNA polymerase II
GO:0006915	apoptotic process
GO:0006979	response to oxidative stress
GO:0008104	protein localization
GO:0009411	response to UV
GO:0009650	UV protection
GO:0035315	hair cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0048568	embryonic organ development
GO:1901990	regulation of mitotic cell cycle phase transition

	Cellular Component
GO:0000112	nucleotide-excision repair factor 3 complex
GO:0000439	transcription factor TFIIH core complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005675	transcription factor TFIIH holo complex
GO:0097550	transcription preinitiation complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7nvy, PDBe:7nvy, PDBj:7nvy
PDBsum	7nvy
PubMed	33902107
UniProt	P19447\|ERCC3_HUMAN General transcription and DNA repair factor IIH helicase/translocase subunit XPB (Gene Name=ERCC3)

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