Structure of PDB 7ml3 Chain 7

Receptor sequence
>7ml37 (length=548) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPLA
EQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDRL
SKVPVAESIINFIKGATISLEEYDFRNDHRNPDLDIDLKPSTQIRPYQEK
SLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVM
QWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSH
DSQKVMDFLTGREWGFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLV
REDDKIGDLNFLIGPKLYEANWMELSQKGHIANVQCAEVWCPMTAEFYQE
YLRETARKRMLLYIMNPTKFQACQFLIQYHERRGDKIIVFSDNVYALQEY
ALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGDTSIDLPEAT
CLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYY
STKRQAFLVDQGYAFKVITHLHGMENIPNLAYASPRERRELLQEVLLK
3D structure
PDB7ml3 Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Chain7
Resolution7.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 7 T463 R464 R466 T245 R246 R248
BS02 dna 7 S458 R464 R466 S240 R246 R248
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000019 regulation of mitotic recombination
GO:0001111 RNA polymerase II promoter clearance
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0005829 cytosol
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ml3, PDBe:7ml3, PDBj:7ml3
PDBsum7ml3
PubMed35051353
UniProtQ00578|RAD25_YEAST General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (Gene Name=SSL2)

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