Structure of PDB 7ml1 Chain 7

Receptor sequence
>7ml17 (length=634) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPLA
EQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDRL
SKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDSV
IGPLRIDSDHQVQPPEDVLEREEEDDDIDAVHSFEIANESVEVVKKRCQE
IDYPVLEEYDFRNDHRNPDLDIDLKPSTQIRPYQEKSLSKMFGNGRARSG
IIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQWCTLQP
ENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGREW
GFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIG
PKLYEANWMELSQKGHIANVQCAEVWCPMTAEFYQEYLRETARKRMLLYI
MNPTKFQACQFLIQYHERRGDKIIVFSDNVYALQEYALKMGKPFIYGSTP
QQERMNILQNFQYNDQINTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQ
EAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSTKRQAFLVDQGYA
FKVITHLHGMENIPNLAYASPRERRELLQEVLLK
3D structure
PDB7ml1 Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II.
Chain7
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 7 T463 R464 R575 T331 R332 R443
BS02 dna 7 S413 S414 V415 T439 S440 D441 S458 R464 N465 R466 S467 K656 S281 S282 V283 T307 S308 D309 S326 R332 N333 R334 S335 K524
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000019 regulation of mitotic recombination
GO:0001111 RNA polymerase II promoter clearance
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0005829 cytosol
GO:0097550 transcription preinitiation complex

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Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:7ml1, PDBe:7ml1, PDBj:7ml1
PDBsum7ml1
PubMed35051353
UniProtQ00578|RAD25_YEAST General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (Gene Name=SSL2)

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