Structure of PDB 7m2u Chain 7

Receptor sequence
>7m2u7 (length=638) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
PADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPLA
EQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDRL
SKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDSV
IGPLRIDSDHQVQPPEDVLEREEEDDDIDAVHSFEIANESVEVVKKRCQE
IDYPVLEEYDFRNDHRNPDLDIDLKPSTQIRPYQEKSLSKMFGNGRARSG
IIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQWCTLQP
ENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGREW
GFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIG
PKLYEANWMELSQKGHIANVQCAEVWCPMTAEFYQEYLRETARKRMLLYI
MNPTKFQACQFLIQYHERRGDKIIVFSDNVYALQEYALKMGKPFIYGSTP
QQERMNILQNFQYNDQINTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQ
EAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSTKRQAFLVDQGYA
FKVITHLHGMENIPNLAYASPRERRELLQEVLLKNEEA
3D structure
PDB7m2u Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair.
Chain7
Resolution8.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna 7 V415 T439 S440 D441 R464 R466 S467 V283 T307 S308 D309 R332 R334 S335
BS02 dna 7 N462 T463 R466 V492 G678 R681 Q682 N330 T331 R334 V360 G546 R549 Q550
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000019 regulation of mitotic recombination
GO:0001111 RNA polymerase II promoter clearance
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0005634 nucleus
GO:0005675 transcription factor TFIIH holo complex
GO:0005829 cytosol
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7m2u, PDBe:7m2u, PDBj:7m2u
PDBsum7m2u
PubMed34099686
UniProtQ00578|RAD25_YEAST General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2 (Gene Name=SSL2)

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