Structure of PDB 6rax Chain 7

Receptor sequence
>6rax7 (length=632) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
RRDYAQDRESIKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDL
DDLAEFNESLAEAVVDNCRRYTSIFSDVIAELLPSEVHAKDALDVYIEHR
LMMEQRDERNSFPSELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVR
GIVTRCTEVKPMMVVATYTCDRCGSETYQPVNSLSFTPVHDCPSDDCRVN
KAGGRLYLQTRGSKFVKFQEVKMQEHSDQVPVGHIPRSMTIMCRGEVTRM
AQPGDHIVVSGVFLPLMRTGFAQMIQGLLSETFLQAHRIICINKNDEISD
KDAELTPEELEELAQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDK
RPDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGL
TAAVMKDPLTGEMTLEGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQ
QTISIAKAGIMTTLNARVSILAAANPAFGRYNPRRTVEQNIQLPAALLSR
FDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKALDMNLMRRYIN
LCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLST
ALARLRLSDSVEKDDVAEALRLLEMSKDSLNQ
3D structure
PDB6rax Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.
Chain7
Resolution3.99 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP 7 I344 D382 G384 V385 A386 K387 Q389 I330 D368 G370 V371 A372 K373 Q375
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005634 nucleus
GO:0042555 MCM complex
GO:0071162 CMG complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6rax, PDBe:6rax, PDBj:6rax
PDBsum6rax
PubMed31484077
UniProtQ9XYU0|MCM7_DROME DNA replication licensing factor Mcm7 (Gene Name=Mcm7)

[Back to BioLiP]